Can You Die From Mono (Mononucleosis)?

By Alicia Wooldridge, MD
Medically reviewed checkmarkMedically reviewed
May 31, 2022

Infectious mononucleosis, also known as mono, is a contagious viral disease.

Because of its prevalence in teenagers and young adults, it’s also sometimes called “the kissing disease.”

The Epstein-Barr virus (EBV) is the most common cause of mononucleosis.

Although most people get infected with EBV in their lifetime, not everyone develops symptoms of mono. When symptoms do appear, they can usually be monitored and cared for at home. 

In some cases, symptoms of mono can persist for several weeks or months.

While these symptoms can cause discomfort and disrupt daily life, they are very rarely life threatening. However, complications of the disease are possible.

In this article, we’ll explore the symptoms, diagnosis, and treatment of mononucleosis and when the infection can cause more serious or life-threatening complications.

What Is Mono?

Infectious mononucleosis is a contagious viral disease.

It is most commonly spread through saliva but can also be spread through other bodily fluids, like blood, semen, and mucus. 

Though the infection is most common in people 15-35 years of age, a person of any age can get mono.


Not everyone exposed to the viruses that cause mono will develop symptoms.

But when symptoms do occur, they can take four to six weeks to appear.

In most cases, symptoms develop slowly.

Common symptoms of mono include:

Other less common symptoms are also possible:

For people who develop symptoms, it can take several weeks for symptoms to resolve. But in some cases, symptoms can persist for six months or longer.


Most providers are able to diagnose mono based on your symptoms and a physical examination of your lymph nodes, tonsils, skin, and/or spleen.

Though laboratory tests are not usually needed to diagnose the infection, your provider may recommend certain tests if your symptoms are atypical. 

Examples of blood tests that can be used to diagnose mono include:

  • White blood cell count test (WBC)
  • Monospot test
  • Antibody test 


In most cases, treatment of mono is focused on relieving symptoms.

This may include:

  • Drinking plenty of fluids
  • Resting
  • Gargling with salt water to soothe a sore throat
  • Using over-the-counter (OTC) pain relievers (like acetaminophen or ibuprofen) if needed

Antibiotics will not help mono, and antiviral medications like acyclovir are also unlikely to provide relief.

But in severe cases, your provider may recommend a prescription steroid medication, like prednisone.


The most common cause of mono is the Epstein-Barr virus.

In rare cases, it can be caused by other viruses and infections, such as:

  • Cytomegalovirus (CMV)
  • Toxoplasmosis
  • HIV
  • Rubella
  • Hepatitis A, B, or C
  • Adenovirus

Talk to a doctor from home.

Start my visit

Can You Die From Mono?

Healthy individuals are very unlikely to die from mononucleosis.

But for people with weakened immune systems, mono can pose a more serious threat.

If you’re immunocompromised, it’s important to speak with your healthcare provider about a safe treatment plan for a suspected or diagnosed case of mono.  

Mono complications

Mono can cause complications, including an enlarged liver and/or spleen, in some people.

It can take several weeks or months for your spleen or liver to recover after infection.

In the meantime, it’s important to avoid alcohol and contact sports, the latter of which could cause your spleen to rupture. 

Other complications of mono are possible.

They include:

  • Anemia
  • Hepatitis with jaundice
  • Swollen or inflamed testicles
  • Guillain-Barré syndrome
  • Meningitis
  • Seizures
  • Bell palsy 

Talk to a doctor from home.

Start my visit

When to See a Doctor

Mono can cause a wide range of symptoms, which can make it difficult to diagnose in its early stages.

If you’re experiencing any symptoms of mono (including fever, fatigue, or weakness) that last for 10 days or longer, reach out to your healthcare provider.

Diagnosing mono early can help you limit the spread to other people and begin treatments that soothe your symptoms as soon as possible.

If you experience any of the following severe symptoms, go to the nearest emergency room or seek immediate medical attention:

  • Sharp, sudden, and/or severe abdominal pain
  • Stiff neck 
  • Severe weakness
  • Trouble swallowing or breathing

How K Health Can Help

Did you know you can get affordable primary care with the K Health app?

Download K Health to check your symptoms, explore conditions and treatments, and, if needed, text with a clinician in minutes. K Health’s AI-powered app is based on 20 years of clinical data.

Frequently Asked Questions

Is mono that serious?
Most cases of mono can be treated at home. In fact, many people who are exposed to the most common virus that causes mono (the Epstein-Barr virus) don’t even develop symptoms of an infection. But if you’re immunocompromised, mono can be dangerous to your health.
When does mono become serious?
In some cases, mono can cause complications that can be serious, including a ruptured spleen, anemia, or meningitis. If you think you may have mono, it’s important to speak with a medical provider who can provide guidance on how best to take care of yourself while you get better.
Can mono be fatal?
In healthy individuals, mono is very unlikely to be fatal. However, if you have an enlarged spleen as a result of a mono infection, it’s important to avoid contact sports, which can rupture your spleen. Unfortunately, mono can be fatal in immunocompromised individuals.
How long can you live with mono?
In most cases, symptoms of mono are mild and go away on their own within several days or weeks. Though some people may have symptoms that persist for six months or longer, mono is not a fatal disease in healthy people. However, the most common virus that causes mono (the Epstein-Barr virus) can stay in a person’s cells for life. Though the virus can reactivate later in a person’s life, it doesn’t usually cause symptoms.
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

Alicia Wooldridge, MD

Dr. Alicia Wooldridge is a board certified Family Medicine physician with over a decade of experience.

Close button

Not feeling well? Talk to a doctor online with K Health.

Start Now