KETOCONAZOLE (kee toe KON na zole) treats fungal or yeast infections. It belongs to a group of medications called antifungals. It will not treat colds, the flu, or infections caused by bacteria or viruses.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
An alcohol abuse problem
History of irregular heartbeat
Low stomach acid production
An unusual or allergic reaction to ketoconazole, itraconazole, miconazole, other medications, foods, dyes or preservatives
Pregnant or trying to get pregnant
How should I use this medication?
Take this medication by mouth with a full glass of water. Follow the directions on the prescription label. This medication works best if you take it with food. Take your medication at regular intervals. Do not take your medication more often than directed. Do not stop taking except on your care team's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medication?
Do not take this medication with any of the following:
Certain medications for anxiety or sleep like alprazolam, midazolam, triazolam
Certain medications for blood pressure like felodipine, nisoldipine, eplerenone
Certain medications for cancer like irinotecan, ibrutinib
Certain medications for cholesterol like cerivastatin, lovastatin, simvastatin, lomitapide
Certain medications for irregular heart rate like disopyramide, dofetilide, dronedarone, quinidine
Ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
Other medications that prolong the QT interval (cause an abnormal heart rhythm)
Red yeast rice
This medication may also interact with the following:
Alcohol or any product that contains alcohol
Antiviral medications for HIV or AIDS
Certain medications for bladder problems like fesoterodine, solifenacin, tolterodine
Certain medications for cancer like bortezomib, busulfan, dasatinib, docetaxel, erlotinib, imatinib, ixabepilone, lapatinib, nilotinib, paclitaxel, trimetrexate, vinca alkaloids
Certain medications for depression, anxiety, or psychotic disturbances like aripiprazole, buspirone, haloperidol, quetiapine, risperidone
Certain medications for erectile dysfunction like vardenafil, sildenafil, tadalafil
Certain medications for pain like alfentanil, fentanyl, oxycodone, sufentanil
Certain medications for seizures like carbamazepine, phenytoin
Certain medications for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
Certain medications for tuberculosis like isoniazid, INH, rifabutin, rifampin, rifapentine
Certain medications that treat or prevent blood clots like dabigatran, rivaroxaban, warfarin
Other medications for fungal infections
Steroid medications like budesonide, ciclesonide, dexamethasone, methylprednisolone
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible:
Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Change in sex drive or performance
Unexpected breast tissue growth
What should I watch for while using this medication?
Visit your care team for check-ups. Tell your care team if your symptoms do not improve. Some fungal infections can take many weeks or months of treatment to cure.
Avoid medications for your stomach like antacids and acid blockers for at least two hours after taking this medication.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
Avoid alcohol while you are taking this medication. Alcohol can increase the risk of liver damage.
If you are going to have surgery, let your care team know that you have been taking this medication.
This medication may cause a decrease in vitamin D. You should make sure that you get enough vitamin D while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.
Where should I keep my medication?
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Keep container tightly closed. Throw away any unused medication after the expiration date.
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.
This information is educational only and should not be construed as specific instructions for individual patients nor as a substitute for medical advice, diagnosis or treatment. Talk to your health care provider or pharmacist about the information and instructions. K Health assumes no liability for any use or reliance on this information.