FLUCONAZOLE (floo KON na zole) prevents and treats fungal or yeast infections. It belongs to a group of medications called antifungals. It will not prevent or treat colds, the flu, or infections caused by bacteria or viruses.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
Irregular heartbeat or rhythm
Kidney disease
Liver disease
Low levels of potassium in the blood
An unusual or allergic reaction to fluconazole, other medications, foods, dyes, or preservatives
Pregnant or trying to get pregnant
Breastfeeding
How should I use this medication?
Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Take all of this medication unless your care team tells you to stop it early. Keep taking it even if you think you are better.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as newborns for selected conditions, precautions do apply.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medication?
Do not take this medication with any of the following:
Adagrasib
Flibanserin
Lomitapide
Lonafarnib
Other medications that cause heart rhythm changes
Triazolam
This medication may also interact with the following:
Abrocitinib
Certain antibiotics, such as rifabutin or rifampin
Certain antivirals for HIV or hepatitis
Certain medications for blood pressure, heart disease, irregular heartbeat
Certain medications for cholesterol, such as atorvastatin, lovastatin, simvastatin
Certain medications for depression, such as amitriptyline or nortriptyline
Certain medications for diabetes, such as glipizide or glyburide
Certain medications for seizures, such as carbamazepine or phenytoin
Certain medications that treat or prevent blood clots, such as warfarin
Certain opioid medications for pain, such as alfentanil, fentanyl, methadone
Cyclophosphamide
Cyclosporine
Ibrutinib
Lemborexant
Midazolam
NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
Olaparib
Sirolimus
Steroid medications, such as prednisone
Tacrolimus
Theophylline
Tofacitinib
Tolvaptan
Vinblastine
Vincristine
Vitamin A
Voriconazole
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible:
Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
Rash, fever, and swollen lymph nodes
Redness, blistering, peeling, or loosening of the skin, including inside the mouth
Seizures
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Change in taste
Diarrhea
Dizziness
Headache
Nausea
Stomach pain
What should I watch for while using this medication?
Visit your care team for regular checkups. If you are taking this medication for a long time you may need blood work. Tell your care team if your symptoms do not improve. Some fungal infections need many weeks or months of treatment to cure.
Alcohol can increase possible damage to your liver. Avoid alcoholic drinks.
If you have a vaginal infection, do not have sex until you have finished your treatment. You can wear a sanitary napkin. Do not use tampons. Wear freshly washed cotton, not synthetic, panties.
Where should I keep my medication?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Throw away any medication after the expiration date.
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.
This information is educational only and should not be construed as specific instructions for individual patients nor as a substitute for medical advice, diagnosis or treatment. Talk to your health care provider or pharmacist about the information and instructions. K Health assumes no liability for any use or reliance on this information.
