PIOGLITAZONE (pye oh GLI ta zone) treats type 2 diabetes. It helps your body use insulin effectively, which decreases your blood sugar (glucose). Changes to diet and exercise are often combined with this medication.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
Bladder cancer
Diabetic ketoacidosis
Eye disease called macular edema
Heart disease
Heart failure
Kidney disease
Liver disease
Polycystic ovary syndrome
Premenopausal
Swelling of the arms, legs, or feet
Type 1 diabetes
An unusual or allergic reaction to pioglitazone, other medications, foods, dyes, or preservatives
Pregnant or trying to get pregnant
Breast-feeding
How should I use this medication?
Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take your medication at the same time each day. Do not take more often than directed.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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CHAT NOWWhat may interact with this medication?
Atorvastatin
Birth control pills or other hormonal methods of birth control
Bosentan
Itraconazole
Ketoconazole
Midazolam
Nifedipine
Other medications for diabetes, including insulin
Topiramate
Many medications may cause an increase or decrease in blood sugar, these include:
Alcohol containing beverages
Aspirin and aspirin-like medications
Chloramphenicol
Chromium
Diuretics
Female hormones, like estrogens or progestins and birth control pills
Heart medications
Isoniazid
Male hormones or anabolic steroids
Medications for weight loss
Medications for allergies, asthma, cold, or cough
Medications for mental problems
Medications called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
Niacin
NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen
Pentamidine
Phenytoin
Probenecid
Quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
Some herbal dietary supplements
Steroid medications like prednisone or cortisone
Thyroid medication
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible:
Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Change in vision such as blurry vision, seeing halos around lights, vision loss
Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Red or dark brown urine, pain or trouble when passing urine, passing frequent amounts of urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Headache
Muscle pain
Runny or stuffy nose
What should I watch for while using this medication?
Visit your care team for regular checks on your progress. You may need regular tests to make sure your liver is working properly.
A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.
Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.
Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.
Tell your care team if you have high blood sugar. You might need to change the dose of your medication. If you are sick or exercising more than usual, you might need to change the dose of your medication.
Do not skip meals. Ask your care team if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.
This medication may increase your risk of having certain heart problems. Get medical help right away if you have any chest pain or tightness, or pain that radiates to the jaw or down the arm, and shortness of breath. These may be signs of a serious medical condition.
This medication may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. You should not take this medication if you become pregnant or think you may be pregnant. Talk with your care team about your birth control options while taking this medication. Contact your care team right away if you think you are pregnant.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medication and dosage times.
Where should I keep my medication?
Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed and protect from moisture and humidity. Throw away any unused medication after the expiration date.
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.
This information is educational only and should not be construed as specific instructions for individual patients nor as a substitute for medical advice, diagnosis or treatment. Talk to your health care provider or pharmacist about the information and instructions. K Health assumes no liability for any use or reliance on this information.
